Obesity is an incredibly complex disease, requiring a multi-disciplinary approach, with many patients being stigmatised due to their weight. Test your understanding of this multi-faceted disease on this set of questions.
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Stem 1, question 1 of 4
Diane, a 56 year old woman, presents to her GP following a recent weight gain
What is the definition of obesity?
An imbalance between energy intake and expenditure
A chronic condition caused by an excessive energy intake
A chronic condition characterised by an inadequate caloric expenditure
A chronic adverse condition caused by excessive appetite
A chronic adverse condition due to an excess amount of body fat
Stem 1, question 2 of 4Leptin, a hormone, is released by adipocytes. What is the action of leptin?
Acts as a hunger signal to promote appetite and decrease substrate utilisation, acting through the hypothalamus
Acts as a satiety signal to inhibit appetite and increase substrate utilisation, acting through the hypothalamus
Acts as a satiety signal to inhibit appetite and increase substrate utilisation, acting through the thalamus
Acts through the vagus nerve on the hypothalamus to increase appetite
Acts on the hypothalamus to decrease appetite and causes gallbladder contraction
Stem 1, question 3 of 4On examination, Diane has central obesity, facial round, thinning of the skin and proximal muscle weakness. What is the most common cause of this presentation?
Adrenocorticotropic hormone secreting pituitary adenoma
Stem 1, question 4 of 4Diane also describes waking up several times a night, not feeling refreshed from sleep and is diagnosed with sleep apnoea. How can obesity cause sleep apnoea?
Decreased tissue mass when relaxed can cause partial or complete airway obstruction
Increased tissue mass when relaxed can cause partial or complete airway obstruction
Increased airway resistance leads to wheezing
Increased tissue mass when relaxed can cause partial or complete airway dilation
Increased laxity of ligaments due to a higher circulating volume of relaxin
Stem 2, question 1 of 5
Oscar, a 34 year old man, presents with recurrent episodes of upper right quadrant pain. Oscar has a BMI of 31.1 kg.m^2
What is the link between gall bladder disease and obesity?
Higher levels of fat mean more cholecystokinin must be produced which overwhelms the capacity of the gallbladder
Decreased metabolism leading to cholestasis and thus stone formation
Higher levels of fat mean fewer bile salts must be produced which underwhelms the capacity of the gallbladder
Higher levels of fat mean more bile salts must be produced which overwhelms the capacity of the gallbladder
Higher levels of fat mean more bile salts must be produced which underwhelms the capacity of the gallbladder
Stem 2, question 2 of 3Which of the following cancers is obesity NOT a risk factor for?
Stem 2, question 3 of 5Oscar takes an anti-depressant. Which of of the following anti-depressants does not cause weight gain as a side effect?
Stem 2, question 4 of 5By what mechanism do anti-psychotics cause weight gain?
Stimulate H1 and 5HT receptors resulting in increased appetite
Stimulation H2 and noradrenaline receptors resulting in increased appetite
Acts via the vagus nerve on the hypothalamus to increase appetite
Stimulate H1 and D2 receptors resulting in increased appetite
Inhibits H1 and D2 receptors resulting in increased appetite
Stem 2, question 5 of 5What is the neural centre for the control of appetite?