Supposedly lymph nodes look like beans…. I’ll let you be the judge of that. Test yourself on this quiz on causes of lymphadenopathy!
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Approach to the patient with lymphadenopathy
Stem 1, question 1 of 4
Esther, 28 year old female, presents to GP with lumps in her neck and above her collarbones. She has been having intermittent fevers and night sweats for last 3 months, but puts this down to her menstrual cycle.What is generalised lymphadenopathy?
Presence of palpable lymph nodes at three discrete locations
Presence of palpable lymph nodes in both superior and inferior to the umbilicus
Palpable lymph nodes in region involved according to the lymphatic drainage patterns
Presence of palpable lymph nodes in three or more chains
Enlargement of more than two contigous lymph nodes groups
Stem 1, question 2 of 4
Esther is presenting with B symptoms (constitutional symptoms)Which of the following are B symptoms? Select all that apply
Stem 1, question 3 of 4
The GP suspects Esther has Lymphoma and arranges further investigationsWhat are the histological features of Hodgkin's lymphoma?
Abnormal B and/or T cells
Multinucleated giant cells
Stem 1, question 4 of 4
A diagnosis of Hodgkin's lymphoma is confirmed and Esther is started on treatmentWhat is the mechanism of action of doxorubicin?
Inhibition of microtubule assembly in mitotic spindle
Inhibition of dihydrofolate reductase and DNA synthesis
Targeting of cells overexpressing Human Epidermal Growth Factor Receptor-2 (HER2) for tumour reduction & destruction
DNA intercalation and inhibition of RNA and DNA synthesis
Stem 2, question 1 of 4
Eliza, a 45 year old female presents with lymphadenopathy, arthralgia, myalgia, morning stiffness and rash. She has no cough.Which of the following is NOT a likely differential for this presentation?
Systemic Lupus Erythematosus
Stem 2, question 2 of 4
3 years later Eliza returns with her 15 year old son, Nick. Nick has extreme fatigue, fever, lymphadenopathy and pharyngitisWhat is the causative organism of Nick's presentation?
Human Immunodeficiency Virus
Epstein Barr Virus
Hepatits B virus
Stem 2, question 3 of 4
Nick is a keen sportsman and is captain of the rugby team at schoolWhy should Nick avoid contact sport for at least 3-4 weeks?
Risk of transmission of disease during contact
Strenuous activity with glandular fever may result in a rash
Potential for hepatic rupture
Potential for splenic rupture
Possibility of Reye's syndrome
Stem 2, question 4 of 4
The GP requests some blood tests for NickWhich of the following is the most likely result?
Negative heterophile antibodies
Low CD4+ count
High Lactate dehydrogenase
Andy presents to A&E with a hot and swollen right arm, he cut his forearm 4 days ago in the woods. Red, warm and tender streaks are visible on the skin of the upper limb. He also has tender axillary lymphadenopathy.What is the most likely cause of the streaks on his arm?
Maria received an insect bite to her umbilicus.Which of the following lymph nodes receive lymph from the umbilicus? Select all that apply