This MCQ tests understanding of basic priciples relating to kidney anatomy (microanatomical structure) and function (ex. main functions of the kidney).
Peer reviewed by Jonathan Loomes-Vrdoljak on 5 August 2019
Intro to the Kidney MCQ
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Question 1 |
How is urinary excretion rate altered by a high reabsorption rate?
It is increased | |
It is decreased | |
It does not alter urinary excretion rate | |
It is not part of the equation |
Question 2 |
What type of cell is present in the thick ascending loop of Henle?
Simple squamous | |
Simple cuboidal | |
Ciliated simple cuboidal | |
Simple columnar |
Question 2 Explanation:
Simple cuboidal cells differ from simple squamous cells in that they have a larger cell volume. Functionally, this indicates that there is increased production or absorption of certain substances by the cell.
The thick ascending loop of Henle is a major absorption site for potassium, sodium and calcium ions, in contrast to the thin ascending loop where no ion absorption takes place (the cells are thus simple squamous here)
Question 3 |
What are the three components of the glomerular filtration barrier and their filtration characteristics?
Fenestrated endothelium (filters based on size and shape), hepatocytes (filters based on size and shape), type 2 pneumocytes (filters based on size and shape)
| |
Blood vessel (filters based on charge), glomerulous (filters based on size and shape), bowman’s capsule (filters based on size and shape)
| |
Fenestrated endothelium (filters based on size and shape), basement membrane (filters based on charge), podocytes (filters based on size and shape)
| |
2 layers of fenestrated endothelium (filters based on size and shape), Basement membrane (filters based on charge) |
Question 4 |
A decrease in blood flow to an interlobular artery could result from stenosis of which artery?
Arcuate artery | |
Afferent arteriole | |
Efferent arteriole | |
Vasa recta |
Question 4 Explanation:
B,C,D are all distal to the interlobular artery
Question 5 |
Outline, in sequence, the blood supply for the kidney beginning from renal artery to venous supply
Renal artery, segmental artery, interlobar artery, arcuate artery, interlobular artery, afferent arteriole, glomerulus, efferent arteriole, peritubular capillaries/vasa recta. | |
Renal artery, interlobular artery, interlobar artery, arcuate artery, segmental artery, afferent arteriole, glomerulus, peritubular capillaries/vasa recta efferent arteriole | |
Renal artery, segmental artery, interlobular artery, arcuate artery, interlobar artery, afferent arteriole, glomerulus, peritubular capillaries/vasa recta, efferent arteriole | |
Renal artery, segmental artery, interlobular artery, arcuate artery, interlobular artery, afferent arteriole, glomerulus, efferent arteriole, peritubular capillaries/vasa recta. |
Question 6 |
What are the main ions contributing to the concentration gradient in extracellular fluid?
Calcium and bicarbonate | |
Potassium, phosphate and inorganic anions | |
Sodium and potassium | |
Sodium and chloride |
Question 7 |
How is urinary filtration rate calculated?
Urinary excretion rate = Filtration rate + Secretion rate + Reabsorption rate | |
Urinary excretion rate = Filtration rate - Secretion rate – Reabsorption rate | |
Urinary excretion rate = Filtration rate + Secretion rate – Reabsorption rate | |
Urinary excretion rate = (Filtration rate + Secretion rate) /Reabsorption rate |
Question 8 |
Which of the following is not produced by the kidney?
EPO | |
1-alpha hydroxylase | |
Angiotensin converting enzyme (ACE) | |
Renin |
Question 8 Explanation:
Angiotensin converting enzyme is produced in the lungs
Question 9 |
How would the basement membrane of the glomerular filtration barrier prevent the passage of albumin?
By repulsion of albumin’s positive charge | |
By having fenestrations smaller than the size of albumin | |
By having fenestrations of different shape to albumin | |
By repulsion of albumin’s negative charge
|
Question 9 Explanation:
The basement membrane has a negative charge which repels albumin's negative charge
Question 10 |
A patient has nephrogenic diabetes insipidus. Which part of the uriniferous tubule is most likely to be affected?
Proximal convoluted tubule | |
Collecting duct | |
Thick ascending loop of Henle | |
Thick descending loop of Henle |
Question 10 Explanation:
ADH acts on the distal convoluted tubule and collecting duct to promote the expression of Aquaporin 2, which reabsorbs water from the filtrate, leading to more concentrated urine and increased hydration.
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