Reviewed by: awaiting review
Pathophysiology of Diabetes MCQ
Glycogen breakdown in the liver
Glucose formation from other macromolecules
Islets of Langerhan
Increase of transmembrane ATPase activity
Inhibition of glycogen synthase
Insulin:glucagon ratio is high
Primarily anabolic state of BMR
Concomitantly unrestrained lipolysis and proteolysis
All of the above
Reduce insulin resistance
Prevent GLP breakdown
Decrease hepatic gluconeogenesis
Alpha cell (islet)
Beta cell (islet)
Prevent breakdown of GLP
Act preferentially on enterocytes of the ileum
Increase secretion of insulin directly
Reduce proximal convoluted tubular reabsorpative capacity.
Type one diabetes
Insulin insensitive diabetes
Decreased carbohydrate utilisation
Stem Question 1/4
A 59 year old female, Julia, presents to her GP frustrated that she is “peeing more than usual” at work. On general examination she has an obese BMI, is hypertensive and has significantly elevated BGC. Other than the given symptom she states she feels fit and well.How is BMI calculated?
weight (g) / height (m2)
Weight (kg) / height (m2)
Height (m2) / weight (kg)
Height (cm2) / weight (kg)
Stem Question 2/4The patient is diagnosed with diabetes. Which HLA-DR type is linked to this form of diabetes?
Stem Question 3/4A patient is found, with further questioning, to have reduced visual acuity and a “blind spot” in her centre of vision. This is best described as?
Stem Question 4/4The patient’s urine is given a Dipstick in clinic which comes positive for nitrites. Why is this the case?
Chronic kidney disease
Elevated glucose in LUTS
Alpha islet cell insufficiency