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This is a quiz on the pathology and pathophysiology of rheumatoid arthritis. Good luck!

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Rheumatoid arthritis

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Question 1
Which of the following is not true of synovial fluid?
A
Is secreted by synovocytes
B
Acts as a metabolite exchange medium
C
Acts as a lubricant for synovial joints
D
Is secreted by a fibrous connective tissue
E
Helps produce the hyaline cartilage of joints
Question 2
Why does the prevalence of  autoantibodies increase with advancing age?
A
Because T-cells are producing antibodies randomly, and as time progresses more of those random antibodies are created
B
Because T-cells are producing antibodies randomly, and as time progresses more of those random antibodies are auto-reactive
C
Because B-cells are producing antibodies randomly, and as time progresses more of those random antibodies are being created
D
Because B-cells are producing antibodies randomly, and as time progresses more of those random antibodies are auto-reactive
E
Because B-cells are producing antibodies randomly until old age when the antibodies begin to proliferate in an uncontrolled manner
Question 3
Which HLA gene is associated with rheumatoid arthritis?
A
HLA-DR2
B
HLA-DR3
C
HLA-DR4
D
HLA-DQ2
E
HLA-B27
Question 4
Which of the following is not a systemic symptom of rheumatoid arthritis?
A
Fatigue
B
Anorexia
C
Weight loss
D
Vomiting
E
Low grade fever
Question 5
Which of the following is not a common deformity seen in the hands in rheumatoid arthritis?
A
Early fusiform swelling
B
Ulnar deviation/MCP subluxation
C
Heberden's nodes
D
Swan neck deformities
E
Boutonniere deformities
Question 6
Which of the following is not a common x-ray finding in patients with rheumatoid arthritis?
A
'Punched out' lesions
B
Loss of cartilage
C
Erosion of bone
D
Damage to joint capsule - subluxation of joint
E
Deformities
Question 7
Which of the following is not a cause of anaemia in rheumatoid arthritis?
A
Active disease
B
Decreased albumin
C
Blood loss
D
Marrow suppression by drugs
E
Felty’s syndrome
Question 8
In what percentage of patients with rheumatoid arthritis is the rheumatoid factor (RF) blood test positive?
A
27%
B
49&
C
70%
D
81&
E
92%
Question 9
Which of the following is not true of corticosteroids in the treatment of rheumatoid arthritis?
A
Reduced transcription of many cytokine genes e.g. ↓IL1, IL2 and TNF
B
Inhibition of transcription factors
C
They can be injected directly into the joint space
D
Reduced clonal proliferation of Th cells
E
Decrease lymphocyte proliferation
Question 10
Which of the following is not true of monoclonal antibody therapy?
A
They can inhibit T cell activation
B
They can inhibit osteoclast activity
C
They can be anti-TNFa
D
They can be anti-CD20 on B cells
E
They can be anti-IL-6
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